Impact of Maternal Emotional Experiences at Birth and Self-Regulation In Preterm Children
The results underline that maternal symptomatology could be a risk factor for the co-construction of interactive exchanges between mother and premature baby and for the long-term development of the infant's self-regulation ability.
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Promising Drug Candidates and Emerging Therapeutic Strategies Against Candida auris
Emerging therapies for Candida auris extend beyond conventional antifungal agents and include repurposed drugs, novel antifungal compounds, vaccines, antimicrobial peptides, and nanotechnology-based approaches. While further clinical validation is needed, these strategies may help address the growing challenge of multidrug-resistant C. auris infections.
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Artificial Intelligence-Assisted Colonoscopy Improves Polyp Detection in a Prospective Randomized Tandem Colonoscopy Study
This prospective randomized tandem study demonstrates that AI-assisted colonoscopy significantly improves overall polyp detection, with the greatest benefit observed for diminutive and Paris type 0-IIa lesions. The enhanced detection was achieved without increasing procedure withdrawal time, supporting the feasibility of real-time AI integration into routine colonoscopic practice. Although false-positive alerts occurred, they were infrequent and readily distinguishable by experienced endoscopists. Given the single-center design, relatively small sample size, and absence of adenoma detection rate analysis, larger multicenter studies are warranted to confirm the clinical impact of AI-assisted colonoscopy on colorectal cancer prevention.
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Ambulatory Antibiotic Prescribing for Acute Sinusitis
Overall, approximately one-third of patients with acute sinusitis did not meet guideline-based indications for antibiotic therapy, yet antibiotics continued to be prescribed frequently in this population. These findings highlight opportunities for antimicrobial stewardship initiatives to improve both prescribing frequency and treatment duration, particularly in clinical settings where adherence to recommended practices is suboptimal, while monitoring potential unintended effects such as repeat healthcare utilization.
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Is Cyanoacrylate Fixation Safe for Neonatal IV Access? A Quality Improvement Evaluation of Cyanoacrylate Adhesive Securement for Short Peripheral Catheters
Cyanoacrylate fixation can support proactive vascular access care, offering a safe and feasible option to prevent complications rather than reacting to them after they occur. No adverse local effects were observed with cyanoacrylate adhesive, suggesting compatibility with neonatal skin and alignment with the Right Patient, Right Device, and Right Care principles within the 7 Rights of Neonatal Vascular Access.
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Efficacy and Safety of Bempedoic Acid in Patients Aged 75 Years and Above Stratified by Varying Statin Exposure
Bempedoic acid was well-tolerated with comparable efficacy and safety across all age categories, except for musculoskeletal disorders in patients receiving concomitant statins. The reduction in MACE-4 was not statistically different among younger and older individuals, supporting the goal of LDL-C lowering with bempedoic acid for cardiovascular prevention in older individuals aged 75 years and above.
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